BRCA1 and breast cancer: BRCA1-associated breast cancers tended to be earlier onset at diagnosis (p = 0.003), and when invasive, were higher grade (p < 0.001), node-negative (p = 0.01), and more commonly TNBC (%TNBC: 69.4% BRCA1 vs. 24.7% BRCA2 vs. 31.6% PALB2; p < 0.001).