In the analytic cohort, the median age at index breast cancer diagnosis was 43 years; 40 years (range 19–72) for BRCA1, 44 (range, 27–80) for BRCA2, and 50 (range, 42–61) for PALB2. Clinical characteristics and treatment details by pathogenic variant are shown in Table 1. Here, BRCA1 is linked to breast cancer.