Our inhibition of HPDGS by PK007 significantly reduced myonecrotic areas in both the tongue and the diaphragm during an early treatment period from postnatal day (p) 18 to p28 – a period that models the acute phase of DMD [2], suggesting that early HPGDS inhibitor intervention could also assist in reducing dysfunction of these specific muscles in DMD. Here, HPGDS is linked to Duchenne muscular dystrophy.