CCL2 and Alzheimer disease: When directly comparing 3w Aβ hiNS(−) with 3w Aβ hiNS(+) we identified genes of interest in AD to be upregulated in the presence of hiMG: CCL2, as already mentioned above, is implicated in AD but its precise role in terms of neuroprotection or neurotoxicity remains elusive [111, 112].