XBP1 also demonstrated a dual significant isoform switch with increased usage of a “spliced” transcript (ENST00000344347, q-value = 0.0416) over the alternate “unspliced” transcript (ENST00000216037, q-value = 0.0260) in ALS patient motor cortex (Fig. 3d). Here, XBP1 is linked to amyotrophic lateral sclerosis.