Notably, a simplified isoform fraction that considered only the expression of the two switched POLDIP3 transcripts (the canonical and exon 3-excluding transcripts) demonstrated that all five brain regions had increased usage of the exon 3-excluding POLDIP3 transcript in ALS patients relative to controls (FigureS16a). The gene discussed is POLDIP3; the disease is amyotrophic lateral sclerosis.