To this point, a study examining C9orf72-positive ALS/FTD frontal and occipital cortex using single-nuclei RNA-seq was only able to detect increased expression of two (STMN2, KALRN) of the 66 previously reported post-mortem TDP-43-associated cryptic splicing events [27] also examined in the present study [92]. Here, C9orf72 is linked to amyotrophic lateral sclerosis.