Previous examination of the STMN2 and UNC13A cryptic exons in bulk CNS RNA-seq found that they were largely detected in the motor cortex and spinal cord of ALS cases, and the frontal and temporal cortices of FTLD cases, the primary sites of pTDP-43 pathology [26, 27, 64]. The gene discussed is UNC13A; the disease is amyotrophic lateral sclerosis.