POLDIP3 and amyotrophic lateral sclerosis: Among these was an isoform switch in POLDIP3 with decreased usage of the canonical transcript (ENST00000252115, q-value = 0.0159) in favour of a transcript excluding exon 3 (ENST00000348657, q-value = 0.0288) in ALS patient cerebellum (Fig. 3c).