To further confirm the effect of BBIT20 on EMT and invasion, an increase of E-cadherin (Fig. 8E and N) and a decrease of MMP-9 (Fig. 8E and O) staining intensities were observed in BBIT20-treated tumours, supporting the inhibitory effect of BBIT20 on tumour dissemination. The gene discussed is CDH1; the disease is neoplasm.