AKT1 and hepatocellular carcinoma: Thioredoxin (Trx) regulates angiopoietin 1 (ANGPT1) splicing by binding to LINC00152, and activation of the ANGPT1 splice heterodimer activates the PI3 K/AKT signaling pathway and up-regulates the expression of EMT-associated proteins, thereby promoting HCC migration and invasion [106].