To confirm the functional relevance of TLR activation by extracellular AD-associated miRNAs in immune cells, primary murine microglia, which express TLR7 and TLR8 [44], were exposed to miR-92a-1-5p, miR-124-5p, miR-9-5p, and miR-501-3p. This evidence concerns the gene TLR8 and Alzheimer disease.