Moreover, increasing studies showed that normal functional microglia autophagy can inhibit NLRP3 inflammasome activity to modulate neuroinflammation, and impairment of microglia autophagy leads to connive excessive NLRP3 inflammasome activation to induce depression-like behaviors (Alcocer-Gomez et al. 2017; Gan et al. 2024; Yu et al. 2021). The gene discussed is NLRP3; the disease is major depressive disorder.