The high-degree nodes in the fibrous cap atheroma plaque network included innate (Degree 9, p < 8.9 × 10–20) and adaptive (Degree 7, p < 4.1 × 10–12) immune systems, Interleukins (Degree 6, p < 9.5 × 10–8), platelet activation (Degree 4, p < 1.45 × 10–5), Cytokines (Degree 4, p < 1.12 × 10–9), and TCR (Degree 4, p < 0.012) pathways and, in the intimal thick/xanthoma plaque network included the Netrin- 1 (Degree 6, p < 0.028), EGFR (Degree 5, p < 0.036), and ERBB2 (Degree 5, p < 0.045) pathways as shown in Tables 7 and 8, respectively. Here, EGFR is linked to xanthoma.