The role of dendritic cells was noteworthy considered in Gram-negative bacterial infections [23] triggering the cytokine, Interleukin, GPCR, IFN, FLT3, EGFR, G alpha, Receptor tyrosine kinase, and TLR signaling pathways and exacerbating their activities by the MQs and VSMCs in vessel microenvironment. This evidence concerns the gene EGFR and gram-negative bacterial infections.