The important pathways of the Cytokines (Degree 4, p < 6 × 10–26), and INF (Degree 4, p < 8.6 × 10–31) in ECs, Cytokines (Degree 4, p < 9.35 × 10–8), and GPCR (Degree 3, p < 1.45 × 10–4) in MQs, NOTCH (Degree 6, p < 0.027) in VSMCs, and Cytokines (Degree 4, p < 1.45 × 10–17) in DCs were found to be activated and enriched after exposure to Gram-negative bacterial infections on the cell networks. Here, CBLIF is linked to gram-negative bacterial infections.