EGFR and xanthoma: Furthermore, the Netrin- 1 (Degree 6, p < 0.028), and EGFR (Degree 5, p < 0.036) pathways were activated in the intimal thick/xanthoma plaque network while the innate (Degree 9, p < 8.9 × 10–20) and adaptive (Degree 7, p < 4.1 × 10–12) immune systems pathways were activated in the fibrous cap atheroma plaque network.