Accordingly, a 2-fold reduction in fibulin-4 expression by itself did not affect heart size (Fig. 3b, h, i), LVEDD (Fig. 3j) or aortic valve function (Fig. 3d) in sham mice, whereas cardiac hypertrophy and remodeling produced by mTAC was aggravated in surviving fibulin-4+/R mice (Fig. 3b, c, e, f) without inducing aortic valve regurgitation in either genotype (Fig. 3d). The gene discussed is EFEMP2; the disease is cardiac hypertrophy.