Surface adhesion molecules expressed by cancer cells (e.g., EpCAM, CD44, and E-cadherin) play a crucial role in the homologous targeting process.14 To verify the homologous targeting abilities of MSF@CCM, the uptake of MSF@CCM was evaluated by normal cells and cancer cells, including human umbilical vein endothelial cells (HUVECs), and mouse embryonic cells (NIH-3T3), squamous cell carcinoma (SCC), human lung cancer cells (A549), human breast cancer cells (MDA-MB-231) and 4T1 cells, respectively (Fig. 3a). This evidence concerns the gene CD44 and cancer.