The development of STING-associated vasculopathy occurs without relying on IRF3.14 Human STING, which functions as a proton channel, has its interferon-inducing ability separated from its key roles in promoting LC3B lipidation and inflammasome activation.15 In phagosomes, STING directly interacted with Src, and this interaction hindered Src from recruiting Syk and phosphorylating it.16 The exploration of STING’s non-traditional immune functions is poised to substantially enrich our comprehension of immune complexity. Here, STING1 is linked to vascular disorder.