IMPDH2 and glioblastoma: Shireman et al. (2021) proved a correlation between de novo purine biosynthesis and chemoresistance; indeed, mycophenolate mofetil, blocking the activity of inosine monophosphate dehydrogenase 2 (IMPDH2) that is a rate-limiting enzyme of purine biosynthesis, increases TMZ efficacy in an in vivo GBM model [28].