This is supported by Rezaei et al. (2023), who suggested leptin as a possible mediator of exercise-induced prevention of memory impairment in T2DM after finding elevated serum and hippocampal levels of this hormone together with decreased hippocampal levels of BACE1, amyloid β and hyperphosphorylated tau after 8 weeks of HIIT training in T2DM rats [114]. Here, MAPT is linked to type 2 diabetes mellitus.