Isolated memory impairment has been reported in AMPAR- [15] and LGI1-Ab AE [23], with the consequent risk of misdiagnosis with AD; additionally, patients with adenylate kinase 5 (AK5)-Abs manifest prominent memory deficits, more often with a rapid evolution, although sometimes few patients can be seen only after the inflammatory phase with isolated bi-hippocampal atrophy [24]. Here, LGI1 is linked to Alzheimer disease.