Among the autoantibodies most frequently associated with manifestations mimicking neurodegenerative disorders—such as dementia, parkinsonism, ataxia and motor neuron disease—IgLON5-, LGI1- and CASPR2-antibodies, predominantly of the IgG4 subclass and associated with specific HLA haplotypes, are the most common. Here, IGLON5 is linked to Parkinson disease.