The accumulation of these dysfunctional cells and their accompanying pro-inflammatory senescence associated secretory phenotype (SASP) contribute to many age-associated pathogenic processes and diseases, including amyloid β (Aβ) and tau pathologies of Alzheimer’s disease and related dementias (AD; ADRDs) [[2], [3], [4], [5]]. The gene discussed is MAPT; the disease is Alzheimer disease.