MAPT and Alzheimer disease: Additionally, we included quantitative assessment of cytokines and chemokines linked to SASP measured in plasma, CSF, and urine; mass spectrometry analysis of AD-associated Aβ and phosphorylated tau isoforms in CSF; metabolite analysis in urine; lipidomic changes in plasma and CSF associated with perturbed lipid metabolism linked to AD [20]; and gene expression changes in peripheral blood mononuclear cells (PBMCs) using a custom transcriptomics panel relevant to chronic stress termed the conserved transcriptional response to adversity (CTRA) [21].