One of the hypermethylated DMRs that is associated with mRNA downregulation involves eukaryotic translation initiation factor 2α kinase 4 (EIF2AK4), a known PAH gene, which underlies pulmonary veno‐occlusive disease (Austin and Loyd 2014; Best et al. 2014, 2017; Eyries et al. 2014). The gene discussed is EIF2AK4; the disease is pulmonary venoocclusive disease.