GSDME is located at the 7p15.3 locus on chromosome 7 and is also known as deafness, autosomal dominant 5 (DFNA5).[129, 130] It is important to note that the overexpression of GSDME is involved in the migration and invasion of tumors and is positively correlated with microvascular density. This evidence concerns the gene GSDME and autosomal dominant nonsyndromic hearing loss.