Suitable GSDMA promoter methylation changes can alter the expression of GSDMA.[128, 179, 180] Furthermore, the silencing of N6‐adenosine methyltransferase Mettl14 disrupts the m6A modification of GSDMC, leading to reduced expression of GSDMC, impaired mitochondrial function, apoptosis of Lgr5+ stem cells, and difficulty in maintaining normal colonic epithelial morphology.[181] Notably, due to the expression of GSDME in tumor sites, methylation regulation of GSDME is more common in various nanomedicine studies. The gene discussed is GSDME; the disease is neoplasm.