However, after pore formation due to pyroptosis, the release of inflammatory cytokines such as IL‐1β and IL‐18 induces local inflammation, triggers the immune response, and amplifies the immune reaction, converting “cold tumors” into “hot tumors.” Therefore, the activation of pyroptosis pathways can target the tumor microenvironment for immune reprogramming to treat cancer. The gene discussed is IL18; the disease is neoplasm.