GSDME is located at the 7p15.3 locus on chromosome 7 and is also known as deafness, autosomal dominant 5 (DFNA5).[129, 130] It is important to note that the overexpression of GSDME is involved in the migration and invasion of tumors and is positively correlated with microvascular density. Here, GSDME is linked to deafness.