GSDMD is primarily expressed in immune cells, predominantly macrophages and dendritic cells, as well as in the placenta, esophageal and gastrointestinal epithelial cells, and various tumor cells.[98, 114, 115, 116] In the human genome, GSDMD is located at the 8q24.3 locus on chromosome 8, with a full‐length molecular weight of 53kDa, of which 31kDa is the N‐terminal domain, and the interface between the N‐terminus and C‐terminus maintains it in an auto‐inhibited conformation.[117] Initially, it was identified due to its homology with other GSDM genes near GSDMC on chromosome 8.[114]. This evidence concerns the gene GSDMD and neoplasm.