TEK and cerebral malaria: Therefore, 3D microvessels have been essential to elucidate several aspects of cerebral malaria, including the effects of differential flow on infected erythrocyte sequestration [37], the dynamics of endothelial inflammatory response mechanisms [38], the roles of BBB cell types in cerebral malaria pathogenesis [16,39], and reproduced the disruption of the angiopoietin-Tie2 axis, a well-known disrupted pathway in patients [39] (Fig 1).