RBFOX3 and Hyperglycemia: Our study revealed that while hyperglycemia significantly reduced the number of NeuN-positive neurons and Nissl bodies in neurons at I/R 1 d, quercetin reversed the neuron loss and Nissl body loss in hyperglycemic CIRI animals, suggesting that quercetin increases the number of surviving neurons, improves neuronal protein synthesis, and protects neurons in terms of both quantity and quality in hyperglycemic MCAO/R rats.