However, further studies are required to elucidate the precise roles of JP4-039-mediated reduction in mito-ROS specifically in vascular endothelium and in cardiomyocytes in ischemic heart in vivo. In order to determine specific contributions of reduction in mito-ROS by JP4-039 in endothelial cells versus cardiomyocytes (and other cell types) to induce coronary angiogenesis and recovery of cardiac function, spatial transcriptomic studies involving post-MI hearts are being carried out in our lab, along with siRNA studies in vitro. The gene discussed is JPH4; the disease is myocardial infarction.