FGF1 and obesity due to melanocortin 4 receptor deficiency: The directions of the changes in FGF1 that we have identified match those Jonker et al. reported where lower levels of FGF1 in the METTL3-deficient mice correlate with protection from diet-induced obesity, and higher levels of FGF1 in mice overexpressing METTL3 lead to exacerbated responses to diet stress.