Even though understanding of TERT regulation and telomerase reactivation in thyroid cancer is crucial to decipher its role in tumor pathogenesis, progression, and aggressiveness, since 2014 that the TCGA research network approached the genomic characterization of PTCs, very few original research studies have focused on investigating somatic TERT CNV (copy number gains or amplification) as a mechanism of telomerase reactivation in thyroid follicular cell tumorigenesis [6–10]. The gene discussed is TERT; the disease is thyroid cancer.