Furthermore, TERT amplification predicts tumor relapse independently of other variables that also exhibit predictive value such as the presence of foci of infiltrative insulae of tumor cells, surrounded by a desmoplastic reaction at the advancing edge of the tumor, presence of areas of focal tall cell appearance, age ≥ 55 years old, male sex, vascular invasion, LNMs at diagnosis, and BRAF mutations. The gene discussed is TERT; the disease is neoplasm.