In an attempt to shed some light on the discrepancies reported so far with respect to TERT amplification, confirm its consideration as a late event in thyroid carcinogenesis, associated with aggressive, advanced stage carcinomas, and simultaneously define its impact on the outcome and survival of PTC patients, in this study, we analyzed 215 tumor samples from 91 patients, who underwent surgery for PTC, poorly differentiated thyroid carcinoma (PDC), or anaplastic thyroid carcinoma (ATC). Here, TERT is linked to neoplasm.