Chronic stress, via local or systemic inflammation, fosters cancer development by altering immune responses, aggravating key tumor hallmarks, and engaging adrenergic, cholinergic, and neurotrophin signaling, establishing the nervous system as a key tumor microenvironment component.1 Preclinical studies have demonstrated that beta-adrenergic receptor (ADRB) activation promotes tumor growth, resistance to chemotherapy, and increased angiogenesis. Here, BDNF is linked to neoplasm.