SRPK1 and cancer: SRPK1 has been implicated in all the cancer hallmarks, SRPK1 expression correlates with advanced disease and poor survival in several cancer indications [15, 43], its expression is elevated in malignant and dysplastic pancreatic tissue compared to normal pancreatic tissue, and, in PDAC cells, SRPK1 silencing inhibits proliferation, induces apoptosis, and enhances the sensitivity to Gem and cisplatin [14].