NLRP3 and leukemia: Interestingly, exposure of human leukemia monocytic cells to Aedes aegypti salivary gland extract results in the downregulation of innate immune, antiviral, and inflammatory-related genes, including NF-kB, IFN-β, NLRP3, and subsequently IL-1β and IL-6, among others, at 24–36 hours (41).