Another study revealed that serum IL-6 concentrationswere significantly higher in both untreated and methimazole-treated patients withGraves’ disease than in controls, with serum sIL-6R concentrations beingsignificantly affected by treatment, whereas IL-1Ra concentrations did not differbetween treated or untreated patients with Graves’ disease and controls (44). This evidence concerns the gene IL6 and glycogen storage disease VI.