Thus, given the relevance polymorphisms in the ARHGAP22 andELMO1 genes appear to have in mechanisms related to thedevelopment of diabetic chronic complications, and considering no previous study hasevaluated the frequency of these polymorphisms in a Brazilian sample, this studyaimed to investigate the association between the rs3844492/ARHGAP22and rs741301/ELMO1 polymorphisms and DKD in patients with T2DM. The gene discussed is ARHGAP22; the disease is type 2 diabetes mellitus.