MECP2 and ischemic stroke: To further investigate the role of neuron‐specific MeCP2 lactylation in ischemic stroke, we employed Mecp2 conditional knock out (cKO) mice lacking neuronal MeCP2, and then over‐expressed either wild‐type (WT) MeCP2 or the K210R/K249R double mutant via adeno‐associated virus (AAV) vectors (Figure5A,B).