Heatmap analysis revealed significant changes in lactylation of non‐histone proteins involved in the regulation of neuronal death following stroke, including MeCP2, AP‐2 complex subunit beta (Ap2b1), microtubule‐associated protein tau (Mapt), nucleophosmin (Npm1), alpha‐synuclein (Snca), and beta‐synuclein (Sncb) (Figure3A). Here, SNCA is linked to Stroke.