MECP2 and ischemic stroke: Neuronal MeCP2 has been reported to function as a transcriptional silencer or activator of specific target genes.[29, 30] In a previous study, MeCP2 was found to participate in neuronal plasticity during stroke via its downstream target genes.[31] In our study, we uncovered a novel neuroprotective mechanism of MeCP2 during ischemic stroke.