Studies have shown that IL‐6 suppresses central mechanisms of feeding,[30, 88] while increases in PGC1α‐dependent muscular expression of kynurenine aminotransferase enzymes alleviate stress‐induced depression.[63] In addition, many studies referred to miR‐1, miR‐206 and miR‐133 as “myomiRs”, noting their high expression levels in skeletal muscle.[89] However, there is limited research on the mechanisms by which exercise induces muscle‐derived miRNAs to regulate the brain. Here, IL6 is linked to major depressive disorder.