Inhibition of miR‐17/20a‐5p led to increased DEPTOR expression, which in turn inactivated the mTOR pathway by preventing 70 kDa ribosomal protein S6 kinase (p70S6K) phosphorylation and enhancing eIF4E‐binding protein 1 (4EBP1) phosphorylation in the hippocampus of CCH rats treated with sEVs (Figure 3I–M). Here, MTOR is linked to columnar cell hyperplasia of the breast.