Based on established markers, we classified them as central venous LSECs (LYVE1, CD32, CD14, STAB2, and CD299), periportal LSECs (LYVE1, CD32, CD14, STAB2, CD299, VWF, and CD31), and portal endothelial cells (VWF and CD31; Figure S21B, Supporting Information).[37, 38] Figure S21C,D (Supporting Information) illustrates the three endothelial cell populations in the tumor and paired normal tissues. This evidence concerns the gene PECAM1 and neoplasm.