The Western blot analysis of IGF2‐treated cells demonstrated increased activation of the IGF2‐related signaling pathway (Figure 4B; Figure S10D, Supporting Information) and the increased expression of HB‐associated proteins, including AFP, OCT4, GPC3, DUSP9, and cMYC, indicating IGF2's role in sustaining hepatoblastoma stemness (Figure 4C; Figure S10E, Supporting Information). Here, GPC3 is linked to hepatoblastoma.