We first performed a transcriptomic evaluation of the two well‐recognized hepatoblastoma cell lines, HepG2 and HUH6, using Pearson's analysis with gene signatures in the public GSE168997 dataset to elucidate IGF2′′s role in hepatoblastoma (AFP, DUSP9, GPC3, DLK1, MYC, EPCAM, KRT8, and LIN28B; Figure S9A, Supporting Information). This evidence concerns the gene GPC3 and hepatoblastoma.