In addition to LPS, AOAH also deacylates and inactivates oxidized phospholipids and lysophospholipids (Zou et al., 2021), Danger-associated molecular pattern (DAMP) molecules that are induced by inflammation and known to contribute to MASLD (Sun et al., 2020; Wang et al., 2022). Here, AOAH is linked to metabolic dysfunction-associated steatotic liver disease.