Intriguingly, nSREBP1 levels increased in the livers of 6–8-week-old (i.e., young) Aoah-/- mice before MASLD developed; the expression of many SREBP1 target genes, such as those involved in fatty acid biosynthesis (Acly, Acaca, Acacb, Fasn, Scd1, Acss2), also increased. Here, AOAH is linked to metabolic dysfunction-associated steatotic liver disease.