Furthermore, Fn1 polymerization is needed for collagen sediment and plays a vital position in myocardial ischemia/reperfusion injury-induced inflammation, myocardial fibrosis, and neovascular formation after infarction (Konstandin et al., 2013; Valiente-Alandi et al., 2018). This evidence concerns the gene FN1 and Myocardial fibrosis.