In addition to measuring hematological parameters, inflammatory cytokine levels, total blood IgE, and OVA-specific IgE levels, we evaluated gross observations of the skin (canine atopic dermatitis extent and severity index) and histological changes to assess RMFE’s modulation of Th2-related immune responses in atopic dermatitis and to explore its anti-atopic mechanisms. Here, IGHE is linked to atopic eczema.