Dogs are susceptible to developing glucocorticoid-induced hepatopathy (16, 20), which manifests biologically as elevated serum activities of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) (4, 21), histopathologically as cytoplasmic vacuolation (22), and clinically as lethargy, polyphagia, polydipsia, polyuria, generalized muscle wasting, semisolid feces, rough hair, and skin rash (4). This evidence concerns the gene GPT and Decreased liver function.