LGI1 and Cognitive impairment: LGI1 is essential for regulating neuronal networks by modulating excitability and synaptic transmission, contributing to neuronal network maturation, and interacting with proteins that control synaptic function, whereas mutations or autoantibodies targeting LGI1 are associated with epilepsy, particularly autosomal dominant temporal lobe epilepsy, leading to cognitive impairments and seizures [2].