In the top 20 high-value proteins in category (a), serine palmitoyltransferase, long chain base subunit 1 (Sptlc1), which is a causative gene product in early onset ALS (ALS27) [28], and Sptlc2 (the highest value) are listed. This evidence concerns the gene SPTLC2 and amyotrophic lateral sclerosis.