TKI, tyrosine kinase inhibitor; NSCLC, non-small cell lung cancer; NCCN, National Comprehensive Cancer Network; ROS1, ROS Proto-Oncogene 1; ALK, anaplastic lymphoma kinase; NTRK, Neurotrophic Tyrosine Receptor Kinase. The gene discussed is ALK; the disease is non-small cell lung carcinoma.