The GCGR G40S allele, which impairs β-arrestin-1 recruitment [15], is associated with T2D, hypertension, altered renal sodium handling, and increased central adiposity in men [38-41], highlighting that impaired GCGR signaling is detrimental despite its key role in promoting hepatic glucose production. The gene discussed is GCGR; the disease is type 2 diabetes mellitus.