However, individuals with the cAMP LoF variant had lower cognitive ability despite a lower prevalance of T2D as compared to nonvariant carrier age- and sex-matched controls, which could suggest that impairments in central GCGR signaling harm cognitive function independently of diabetes Therapeutic interventions activating GCGR signaling remain to be assessed in connection with their impact on cognitive health. Here, GCGR is linked to type 2 diabetes mellitus.