The recurrence of mutations in these genes is between 3 and 31 (Supplementary Fig. S3A). TTN (titin) and CSMD3 (CUB and sushi multiple domains 3) exhibit the most mutations (n = 31 and n = 19), which is likely due to their large coding regions and unlikely to be selected for in cancer cells by gaining a fitness advantage. The gene discussed is TTN; the disease is cancer.