,141,142 In addition, as a tryptamine phosphoramidate prodrug of 7-benzyl guanosine monophosphate (7Bn-GMP), 4Ei-1 blocks eIF4E cap binding and triggers proteasomal degradation of eIF4E, thereby overcoming gemcitabine resistance in breast and lung cancers.139. The gene discussed is EIF4E; the disease is lung carcinoma.