In the context of esophageal cancer, the interplay between FMR1 and lncRNA HOXA cluster antisense RNA 4 (HOXA10-AS), which stabilizes homeobox A10 (HOXA10) mRNA and subsequently regulates the expression of choline dehydrogenase (CHDH), exemplifies the complex layers of post-transcriptional control in cancer cell growth mediated by FMRP.217. The gene discussed is CHDH; the disease is cancer.