In prostate cancer, the narrative unfolds with modified circular RNAs RBM33 (circRBM33) engaging FMR1 (the gene encoding FMRP) to form a complex that preserves pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1) mRNA stability, a critical player in metabolism.213. The gene discussed is PDHA1; the disease is Familial prostate cancer.