The RBP FMRP can also bind to circular RNA CHAF1A (circCHAF1A) and promote its expression by maintaining its stability, while homeobox C8 (HOXC8) also transcribes FMRP expression to form a feedback loop, which may be involved in the malignant transformation of glioma. The gene discussed is FMR1; the disease is glioma.