In contrast, tumor cells with low or absent FMRP expression promote the secretion of C–C motif chemokine ligand 5 (CCL5), C-X-C motif chemokine ligand 9 (CXCL9), and C-X-C motif chemokine ligand 10 (CXCL10) from macrophages to create an immune activation microenvironment in cooperation with C–C motif chemokine ligand 7 (CCL7). Here, CXCL10 is linked to neoplasm.