However, RANBP2 was identified as an interacting partner with LASP1, facilitating the SUMOylation of LASP1, thereby leading to the up-regulation of human epidermal growth factor receptor 2 (HER2) expression in hepatoma cells, which is usually up-regulated in HCC as a key signaling molecule and potential therapeutic target.46 This evidence concerns the gene LASP1 and hepatocellular carcinoma.