The SUMOylation by RANBP2 acidifies nuclear factor IL-33, thereby disrupting the ubiquitin-mediated protein degradation of interferon regulatory factor 1 (IRF1) and transcriptionally enhancing the expression of programmed death receptor ligand 1 (PD-L1), an immune-supporting factor in the tumor microenvironment. This evidence concerns the gene RANBP2 and neoplasm.