PIAS3 and glioblastoma: In glioblastoma multiforme, the most malignant intracranial neoplasm, originating from glial cells,100, 101, 102 Li et al scrutinized the SUMOylation regulatory factors and discerned that UBE2I, ubiquitin like modifier activating enzyme 2 (UBA2), protein inhibitor of activated STAT 3 (PIAS3), and SENP1 exhibit heightened expression levels in glioblastoma multiforme, while conversely, PIAS1, RANBP2, SENP5, and SENP2 manifested down-regulation in this context.