Meanwhile, another study reported that PAX8 staining was positive in 26 (76%) ATC cases, including all 16 squamodisc variants, 7 (58%) giant cell/pleomorphic variants, and 3 (50%) spindled variants, and all head and neck squamous cell carcinomas were negative for PAX8 contrastly.364. The gene discussed is PAX8; the disease is head and neck squamous cell carcinoma.