Phosphatase and tension homologs (PTEN) are important inhibitors of human cancer73 with C-terminal PDZ domain-binding MOBS (PBM) that can be recognized by scaffolding proteins and regulatory proteins and bind specifically to the PDZ domain to suppress tumor growth.74, 75, 76 RGS12 interacts with PTEN through the PDZ domain, up-regulating phosphorylation and sumoylation of PTEN, thereby inactivating the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway and suppressing OSCC growth.72 The gene discussed is RGS12; the disease is neoplasm.