In contrast, METTL3, as a methyltransferase, plays a pro-cancer role in AML by increasing the half-life of ITGA4 mRNA through m6A methylation, thereby elevating ITGA4 protein levels and facilitating chemoresistance through enhanced AML cell homing and engraftment (Li M. et al., 2022). This evidence concerns the gene METTL3 and acute myeloid leukemia.