Similarly, hypoxia-induced upregulation of hypoxia-inducible factor-1α (HIF-1α) transcription increases the expression of the lncRNA STEAP3-AS1, which competes with YTHDF2 to stabilize STEAP3 mRNA and protein expression, further facilitating CRC advancement (Zhou L. et al., 2022). Here, YTHDF2 is linked to colorectal carcinoma.