Additionally, IGF2BP3 is involved in the initiation of a circRNF10/ZBTB48/IGF2BP3 positive feedback loop in gliomas, leading to reduced Fe2+ accumulation and activation of ferroptosis defense mechanisms, which promotes glioblastoma (GBM) progression (Wang C. et al., 2023). Here, IGF2BP3 is linked to central nervous system cancer.