In contrast, METTL3, as a methyltransferase, plays a pro-cancer role in AML by increasing the half-life of ITGA4 mRNA through m6A methylation, thereby elevating ITGA4 protein levels and facilitating chemoresistance through enhanced AML cell homing and engraftment (Li M. et al., 2022). The gene discussed is ITGA4; the disease is cancer.