ITGA4 and acute myeloid leukemia: In contrast, METTL3, as a methyltransferase, plays a pro-cancer role in AML by increasing the half-life of ITGA4 mRNA through m6A methylation, thereby elevating ITGA4 protein levels and facilitating chemoresistance through enhanced AML cell homing and engraftment (Li M. et al., 2022).