A recent study on hepatocellular carcinoma (HCC) found that ferroptosis is regulated by the PPARGC1A/BAMBI/ACSL5 axis, with METTL3 and WTAP inhibiting PPARGC1A in an m6A- and YTHDF2-dependent manner. The gene discussed is PPARGC1A; the disease is hepatocellular carcinoma.