Diseases associated with SCN5A mutations include the long QT syndrome (LQTS), Brugada syndrome (BrS), isolated (progressive) conduction defect (Lev–Lenègre syndrome), atrial fibrillation, sick sinus syndrome, multifocal ectopic premature Purkinje-related complexes, and DCM. This evidence concerns the gene SCN5A and sick sinus syndrome.