TNFSF11 and Miyoshi myopathy: Furthermore, when establishing MM organoids, the addition of the cytokine, receptor activator of nuclear factor kappa-B ligand (RANKL), facilitates the generation of osteoclasts, while the inclusion of macrophage colony-stimulating factor (M-CSF) synergistically functions with RANKL to support the bone resorption process (Visconti et al., 2021; Anloague et al., 2024).