Multiple studies have highlighted the involvement of TRPC channels, including TRPC1, TRPC3, and TRPC6, in cardiac and renal fibrosis (He et al., 2014; Camacho Londoño et al., 2015; Saliba et al., 2015; Wu et al., 2017; Saliba et al., 2019; Wang et al., 2024). Here, TRPC3 is linked to renal fibrosis.