Notably, researchers Cheng and Zhang et al. constructed a nanoparticle CTLH NP(containing Tempol, a SOD mimetic with ROS scavenging capabilities), which achieved targeted thrombolysis in pregnant rats with deep vein thrombosis (DVT) by inhibiting platelet aggregation, promoting thrombolysis, reducing local inflammation, attenuating oxidative stress, and promoting endothelial repair (Figure 8A; Table 3) (Cheng et al., 2022). Here, SOD1 is linked to deep vein thrombosis.