CRP and infection: CRP significantly affects CL similar to several studies (Pepys and Hirschfield, 2003; Encalada Ventura et al., 2015; Jiang et al., 2022; Boglione-Kerrien et al., 2023), CRP is an acute protein in the plasma in the presence of infection or tissue damage to the organism, a non-specific inflammatory marker produced mainly by hepatocytes, especially in hepatocyte injury, infection and inflammation increase dramatically, plasma CRP levels can reflect the severity of inflammation.