This study also explored the effect of other covariates on VRC PK in patients with CAPA and found that C-reactive protein (CRP), glutamyl transpeptidase (GGT), platelet count (PLT) and aspartate aminotransferase (AST), as well as the use of continuous renal replacement therapy (CRRT), had a significant effect on CL. Here, CRP is linked to episodic ataxia type 2.